Kathy GriffinComedian Kathy Griffin is opening up about her struggles with low self-esteem -- which lead her to try plastic surgery and weight loss diets. After moving to Hollywood, Griffin was pressured to look perfect and had her first surgery, a nose job, at age 26.

"I was told repeatedly, 'You would be pretty if it weren't for that nose. You'd work more if it weren't for that nose.' You would think I had a nose the size of Texas. I was young and impressionable and started to believe it, so I got a nose job," she told PEOPLE. And that was only the beginning.