As stars of reality show 'Giuliana & Bill,' Bill and Giuliana Rancic are used to sharing their world with fans. And when they started fertility treatments, specifically IVF treatments, this past spring, they shared that too.

But after getting pregnant on the first try, Giuliana suffered a miscarriage at nine weeks--and the couple was devastated.

"Both of us were in shock," Bill, 39, told PEOPLE. "Failure wasn't an option!" Giuliana said she was wrecked by the news. "I said, 'I'm not doing this again. I can't.' I was angry at life and at God," she reveals.

Their reality show, which returns on October 11, will capture the highs of finding out she's pregnant and the lows after the miscarriage. They hope it will help other couples that are struggling with similar issues.