John MayerThe Comedy Fights Malaria campaign takes a brand-new approach to an age-old health issue, using humor to keep malaria in the spotlight. Featuring a broad range of stars, including Ed Helms, John Mayer, Elizabeth Banks, BJ Novak and Nick Kroll, the organization hopes to raise awareness for the disease.

"Comedy Fights Malaria is a fresh, different and truly funny way to get people thinking about a serious opportunity to save lives," B.J. Novak, who stars in 'The Office' and is a creative force behind the campaign, said in a press release.

But Comedy Fights Malaria is also quick to note that the disease itself is no laughing matter -- every 45 seconds, a child in Africa dies from malaria.