Call them the new odd couple. America's sweetheart Jennifer Aniston and sassy-pants comedienne Chelsea Handler are new best friends! "Jennifer wanted to get away for Thanksgiving and hired two private planes to bring a bunch of friends to celebrate with her at a private home in Cabo San Lucas," an insider tells me. "Jen has more money than she will ever be able to spend in her lifetime, so she decided Thanksgiving was the perfect time to splurge on the most important people in her life."

And showing just how caring and thoughtful she can be, my source reveals that Jen "made sure Chelsea had plenty of vodka."