After spending Thanksgiving in Mexico with BFF Jennifer Aniston, tart-tongued funnywoman Chelsea Handler didn't hide her feelings towards Angelina Jolie at her show in Newark, New Jersey Friday night, calling Angie a home-wrecking "b***h" who doesn't have any female friends because she's a [c-word].

"Chelsea hates Angelina and doesn't for one second buy that she is this good person rescuing children in need around the World," a friend of the comedienne tells me. "Everyone in Hollywood is scared to say what they really think about Angelina except Chelsea."