Audiences love potty-mouthed comedienne Kathy Griffin, 50, who has jumped from D-list to A-list in the last few years. She made her name as a stand-up comic in club appearances and on her clever, Emmy-winning Bravo TV reality show, 'My Life on the D List.' Now the funny lady is packing the house -- she recently had to add two shows -- in New York with her hilarious new Broadway show 'Kathy Griffin Wants a Tony.'

Then there's Chelsea Handler, 36, who, in addition to hosting E!'s nightly 'Chelsea Lately,' has a new second E! show ('After Lately'), a sitcom in-the works for NBC based on her life and her own new book imprint label, for which she has a three-book deal, with one tome planned to be written through the eyes of her dog Chunk.

Both funny ladies trash celebrities, poke holes in popular culture and talk about who they want to schtup. Even though each excels on stage with in-your-face humor, have great timing and can roll their eyes like nobody's business, their styles are different, and as their respective empires continue to expand, it seems like only a matter of time before one of them makes a play for a big-time late-night network chat fest. But which funny lady is better suited for a network gig?