Zach Galifianakis, Bradley Cooper and Ed Helms make more than just trouble -- they make money. Raking in record numbers at the box office, 'The Hangover: Part II' is launching the summer movie season with a 4-day Memorial Day weekend take (Friday-Monday) of approximately $105 million, as estimated today by Deadline.

The dudes-in-distress sequel scored the largest opening ever for an R-rated comedy, and it dominates first place over other two sequels also raking in big bucks right now. In second place: Jack Black and Angelina Jolie's 'Kung Fu Panda 2,' predicted to make $62 million for the four-day holiday period in its premiere weekend in theaters.

Johnny Depp's 'Pirates of the Caribbean: On Stranger Tides,' which opened a week ago, is estimated to make another $53 million this Memorial Day weekend, followed by Kristen Wiig's 'Bridesmaids,' expected to earn another $21.5 million.