Missy Elliot Graves DiseaseFor three years now, Missy Elliot has been battling Graves' disease, the hip-hop artist divulged to People. The disease, which takes a dramatic tole on the autoimmune system and thyroid, has been so debilitating to the star that she has had to dramatically change her everyday life.

"I was [driving and] trying to put my foot on the brake, but my leg was jumping," she recalled. "I couldn't keep the brake down and almost crashed. I couldn't write because my nervous system was so bad -- I couldn't even use a pen."

But the disease has not only had a physical affect on the star, it has also taken a told on Eliott's mental facilities. The 'Work It' singer was also plagued with mood swings and hair loss while undergoing radiation for hyperthyroidism.